Ek Duje Ke Vaaste 2|Chat Club#10 - Page 77

i never liked biology tbh but the inhibitors that are primarily made in pharma companies to inhibit the target enzyme's function if we tend to picturize the lock and key model here (the medchem group that i'm part of for my company)...but again IMO lock and key model is an approximation tbh...

Originally posted by: Meena_J

yes i saw the video...it was quite interesting but my question was how would inject it in vivo? esp when to the point when its metastasized...i would like to see more studies on this topic..

I wonder if he's talking about initial stages of cancer only...because I was wondering the same thing about what if the cancer has metastasized. That's also a good question as to how it would be injected...in class when we talked about crispr, we talked delivering it via plasmid vector but even with that how do you get that inside the body and make sure it targets the right place?...I feel like I kinda understood that nitty gritty part but the never got the big picture...

Originally posted by: Meena_J

i never liked biology tbh but the inhibitors that are primarily made in pharma companies to inhibit the target enzyme's function if we tend to picturize the lock and key model here (the medchem group that i'm part of for my company)...but again IMO lock and key model is an approximation tbh...

LOL I chose biology as my major so I wouldn't have to take more calculus (I suck at math)...but my favorite classes were biochemistry and inorganic chemistry. My biochem prof always preferred induced fit model and it actually makes more sense to me because having a single active site where numerous substrates can fit and have different functions seems more efficient

Originally posted by: alina.b

I wonder if he's talking about initial stages of cancer only...because I was wondering the same thing about what if the cancer has metastasized. That's also a good question as to how it would be injected...in class when we talked about crispr, we talked delivering it via plasmid vector but even with that how do you get that inside the body and make sure it targets the right place?...I feel like I kinda understood that nitty gritty part but the never got the big picture...

Originally posted by: alina.b

Yeah...what's up with Mohit 😆 so many updates on IG in the past few days...boy remembered than he has crazy fans who miss him on TV 😭

Cases are still rising so I can understand we they are hesitant to restart shoot...at least they are thinking of their cast/crew because some people here have become so money-minded that they said they don't care if people die but the country won't close down again...

Yes! I am grateful that he remembers us😆

Yes! I want the crew to be safe... can wait for some more time!😳

Good health comes above money anytime!

Originally posted by: alina.b

OK so I just watched this! It was very interesting to watch! One thing that I was a bit confused about towards the beginning was that he seems to emphasize a lot on the lock-and-key model but during my education, my professors always said that the lock-and-key model wasn't very accurate and that the induced fit model is really what's more ideal...idk how true that is or maybe Mukherjee was just using lock-and-key as an example because it's easier to understand.

So, I found this TED talk interesting because, again in college, I was always taught to think in a series of have disease -> take medicine -> kill disease. In my genetics lab course, our final project was about "creating a cure" for a genetic disease. Maybe because it was specifically a genetics course, but when we talked about personalized medicine, we were taught to think "attack the faulty part" of the genome and "fix" the mutation. We focused a lot on RNAi, CRISPR and transgenic rescue. LOL tbh I still don't completely understand them 😆

So, it was an interesting approach that Mukherjee took with organization of life system...what we learned in Bio 101: cells -> tissue -> organ -> organ system. So, maybe we need to go back to the basics and instead of getting caught with the details, we need to look at the bigger picture. He talked about using stem cells. It's still personalized medicine but instead of getting into the nitty gritty of the genome, you introduce one of your own cells to "fix" the problem. So, the example he gave for OA, made sense to me...you basically "grow" cartilage...but I don't understand how this would work for cancer. He talked about introducing a cell with apoptotic properties and I wish he had gone more in depth about that...because is he talking about injecting that directly into the tumor to kill it? What if it's metastasized cancer? Idk...sorry if I sound stupid because I haven't learned much about stem cells. Also, cancer is something that I've struggled to understand. Ironically, despite being a biology student, I've always sucked at it 😭 Thanks for sharing this video with me!! LOL you inspired me to pull out some of my old notes and projects to review...I've got some brushing up to do.

Alina........swamped with work............just sent you a message........with the papers will help you to understand..........a bit of his talk.......you've to divide Dr. Mukherjee's talk into 3 different periods...He covered and link a whole lot of scientific models, metaphors, and mechanisms where he didn't have a chance to go in-depth for any.........guess.......looking at the small glimpse of the attendees......it was solely for professional scientists.......going to basic might not being in his intention either.....for this particular talk.....however.........@1st bold L&K he used to show how treatment/targeted therapy happened in the past.......@2nd bold.............he talked about skeletal regeneration........osteoporosis........& other diseases...for that part........not specifically about cancer.......right there............later on he used cancer as an example.........as similar mechanisms can be studied and methods can be applied after modifications for different...diseases........ @3rd B...........it's a little different mechanism...he tried to explain immunotherapy........what involves way more ways of using patients' own cells then just injecting them...

OK...sorry.........to other folks for making this a scientific discussion thread..........

@Lavy

मी भाजी निवडत होते

and I was frustrated

so I watched Naagin 3🤣😔

Originally posted by: Bacillusbadius

@Lavy

मी भाजी निवडत होते

and I was frustrated

so I watched Naagin 3🤣😔

Ag bai!😲😆

(OMG reaction!)

What did you do Bhagu?😆

You literally watched the evergreen Naagin😲🤣

Will reply to the further msgs tom! I am going to sleep!

@Isa do check Pg 89 of this CC!

Originally posted by: Meena_J

koi h

Main hoon!

But going to sleep now!

So Hi as well as Bye😆

100 pgs completed 😃