OK so I just watched this! It was very interesting to watch! One thing that I was a bit confused about towards the beginning was that he seems to emphasize a lot on the lock-and-key model but during my education, my professors always said that the lock-and-key model wasn't very accurate and that the induced fit model is really what's more ideal...idk how true that is or maybe Mukherjee was just using lock-and-key as an example because it's easier to understand.
So, I found this TED talk interesting because, again in college, I was always taught to think in a series of have disease -> take medicine -> kill disease. In my genetics lab course, our final project was about "creating a cure" for a genetic disease. Maybe because it was specifically a genetics course, but when we talked about personalized medicine, we were taught to think "attack the faulty part" of the genome and "fix" the mutation. We focused a lot on RNAi, CRISPR and transgenic rescue. LOL tbh I still don't completely understand them 😆
So, it was an interesting approach that Mukherjee took with organization of life system...what we learned in Bio 101: cells -> tissue -> organ -> organ system. So, maybe we need to go back to the basics and instead of getting caught with the details, we need to look at the bigger picture. He talked about using stem cells. It's still personalized medicine but instead of getting into the nitty gritty of the genome, you introduce one of your own cells to "fix" the problem. So, the example he gave for OA, made sense to me...you basically "grow" cartilage...but I don't understand how this would work for cancer. He talked about introducing a cell with apoptotic properties and I wish he had gone more in depth about that...because is he talking about injecting that directly into the tumor to kill it? What if it's metastasized cancer? Idk...sorry if I sound stupid because I haven't learned much about stem cells. Also, cancer is something that I've struggled to understand. Ironically, despite being a biology student, I've always sucked at it 😭 Thanks for sharing this video with me!! LOL you inspired me to pull out some of my old notes and projects to review...I've got some brushing up to do.