I am sure most of us have gone through this kind of guilt trip in our life at some point where we have felt really worried, concerned for a almost stranger. As humans we don't feel indifferent when the people around you are worried, tensed regarding the life of their beloved one. Same was with Anika, she was obiviously concerned even Ishana and Sowmya were, but Anika had more to worry because she had wish not to see Shivay's face forever just some hours back and now his life is in danger. She was guilty, the flashbacks of those words were haunting her and it dint look any extraordinary to me, the CVs conveyed her guilt by making her talk to daadi about how she shouldn't have wished bad, how sometimes the words just turn out to be true etc.
She guilty infact very guilty and tomorrow she will be more worried because let's be real, we all will be heartbroken if the person whom we talk everyday, encounter everyday dies suddenly.
Regarding OmRu not shown being broken, their faces were surely worried but not shown to be melodramatically broken, crying etc because they were trying to be optimistic and strong like rest in the family as Shivaay is just not reachable for the moment, they haven't seen him hurt yet. I am sure tomorrow we will see their outburst with melodrama. Also 22 mins can't focus on detailed emotions of each character, so we can't jump to conclusions without seeing the next episode.
Btw, I found it so adorable and sad same time when Anika said God hasn't answered any of her wishes till now, so she is sure this wish too won't be answered.