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Many patients in need of a transplant will not have a matched family member or unrelated donor. A protocol developed at the Johns Hopkins Kimmel Cancer Center in 2000 has shown that half-identical, or related donors can be performed with similar outcomes to that seen with matched transplants. All parents and children, and about half of siblings, are half matches. The ability to perform haploidentical transplants has revolutionized BMT, so that almost everyone now needing a transplant can get one. This approach developed at Johns Hopkins is now being studied at most of the major transplant centers around the country.
While not all half-siblings--or full siblings for that matter--will be HLA-matched, if the patient's half-brother is HLA-matched and healthy enough to donate, he may be a viable donor.