For me, it is Draupadi and Bhishm.
Draupadi bcoz, she had to go through physical assault, public humiliation, losing all her children, and living with that pain for 36 years, living in exile, etc. She did have some advantage of being the wife of 5 men, but that complicated her life a lot, and this polyandry brought more pain to her than, happiness.
And by the way, Draupadi went to exile only ONCE, if I'm not mistaken, for 13 years.
Apart from Draupadi, it was certainly Bhishma.
Bhishma sacrificed his throne, his life, his right to be happy, everything.
Giving up throne is one thing.
But the fact that he remained a celibate for ,I don't know ,how many years, maybe 100...that's a huge sacrifice. He did not marry, did not have children, and that is the biggest sacrifice, in my opinion.