The fresh storyline kicks off with the interns now becoming resident doctors giving way to a pack of fresh new interns entering the hospital to up the entertainment quotient.
Coming from different walks of life, four new youngsters join in the struggle to become flourishing medical professionals. Among the fresh interns, playing Tamanna is Moulshree Sachdeva, essaying the role of a quintessential girl, hailing from a humble background. Extremely focused, she is a girl toiling to be a doctor, to fulfill her father's dreams.
In sheer contrast to her is Siddhanth Modi's character portrayed by current teenage heartthrob Karan Wahi. He plays a rich spoilt brat from USA pursuing the internship owing to his lineage. Packed off to Sanjeevani, against his will, he comes to Sanjeevani to get a first hand feel of India under the strict supervision of Dr Abhimanyu, who is his cousin.
Coming to the show as Naina Mehta, Neha Jhulka, is an absolute firebrand, belonging to an affluent Gujrati family. She loves to be cool in spite of being from a conservative family and is ready to go to any lengths to stay so! Playing the role of Yuvraj is newcomer Sehban Azim, a guy with an ambition and the determination to achieve it, a straight talker and serious worker, a perfectionist in line to become Dr Shasank's favourite.
Yuvi stays away from the jing bang. He is an island and not interested in anybody else's activities. Perhaps this is what attracts the motor-mouth Naina (gujju girl) to him. He bluntly tells her to stay off, but she never gets his hints. Or just disregards them. He tells her time and again that she will get singed if she tries to come close. But their friendship happens eventually. And she becomes the only person who Yuvi develops trust on. Naina keeps telling him how much opposite they are - he is silent and always speaks the truth. And she can never be silent and always lies - perhaps that's they gel.
Yuvi and Sid start off by not liking each other but in time they become good friends. They are a good combination and have a male bonding going. But at some point of time they will have a tiff and will turn the fiercest of enemies. In the beginning, Yuvi will be Shashank's blue eyed boy and Sid the irritating brat. But later, Shashank influences Sid's life positively Sid takes to Shashank and subsequently takes up for him. Yuvi and Sid become arch rivals.
Sid and Tamanna will find each other involved in each others matters in one way or the other and more oft than not the perfect-proper Tamanna will find her in a spot cause of some fool hardy of Sid! Sid turn around will happen finally when he sees that his antics are putting Tamannas dreams -hard work in bad light!
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Dr Siddhant Modi
A smart and spoilt brat from a filthy rich NRI family. Everybody is a doctor in his family, so he has been sent to India to get real and focused. But for Sid life is a one big PS3 game. He is never serious about anything in life and has a general disregard for everything.
He didn't want to become a doctor as it takes a lot of hard work. A complete gadget freak wants to get out of this filth and go back to his high life in Houston. Sid loves to flirt but will never commit, he is an overgrown temperamental kid. The shrew who needs to be tamed. But he is capable of being brilliant because with minimal effort he does well.
Dr Tamana Patil
A girl with middle class moralities. She is focused on her career and doesn't get distracted. She is the reliable and responsible daughter of her parents. Tamana has a high sense of justice, is simple yet smart, sensitive and compassionate. She is the star of her chawl. She is always seen in salwar kameez with distinct style and look. On her rests the hopes dreams of her family.
Dr Naina Mehta
Naina is from a rich but orthodox gujju family and is the youngest of six siblings. But she's not the one to compromise on anything -she'll work her way around all stuff. She is a convincing and a shameless liar, but does not to hurt anyone. Her parents want to arrange her marriage but she is interested in her career.
She always maintains a dual identity leaving home wearing a salwar kameez and transforming into spaghetti straps and minis. Always high on energy and life like a firebrand and bindaas. Is a chatterbox and slightly dumb. Loves trying out new things and experimenting. She has a point to prove to herself which makes her rebellious in a positive way.
Dr Yuvraaj
He is a middle class boy with a modern outlook. Has the responsibility of his family on him with a working mother and a younger sister. Life for him is a series of discoveries. He is serious and focused and believes that medical practice is not only a science but also an art.
He has a wicked sense of humor full with one liners and wise cracks. Always takes stands and has opinions making him the most balanced and matured person amongst all the other interns. You can always put your money on his future. He goes on to become Dr Shashank's proxy guy - but little does anyone know. That he hides as a deep secret.