She has acted in Telugu , Tamil, Kannada, Hindi as well as Malayalam films.
After becoming successful in cinema, Radhika wanted to do something different and decided to take on the small screen. In 1994 she set out to produce her own TV software under the Radaan TV banner.
In recent years she has acted as the title character in several hit megaserials produced by her company, Radaan Mediaworks. Her first hit drama was Chitti, a 488-episode serial in which she portrayed the main character, Saradha. The serial was widely watched and praised throughout the Tamil-speaking world. Fresh off the success of Chitthi, Radhika went on to produce another, longer Tamil serial, the 757-episode Annamalai, in which she once again played the main role. Her co-star in both these first two serials was the veteran actor Sivakumar, with whom she was often paired in films as well. However, in Annamalai, he played her eldest brother. She recently played a dual role in the teleserial Arasi, the sequel to the teleserial Selvi. Arasi has also recently been completed and is followed by yet another serial featuring herself called Chellamey