"Sussanne has decided to separate from me and end our 17-year relationship. This is a very trying time for the entire family and I request the media and the people to grant us our privacy at this time," said the 39-year-old in a statement.
The news has come just a few days before their 13th marriage anniversary. The duo tied the knot Dec 20, 2000 post the success of Hrithik's debut film "Kaho Naa... Pyaar Hai". They have two sons - Hrehaan and Hridhaan.
"I do not wish this news to disempower my fans and the people about the institution of marriage in any way. I am a firm believer in this institution and respect and honour it at the highest level...," he said.
Last month Hrithik headed to an undisclosed location abroad for his medical treatment. The "Krrish" star has been suffering bouts of headache. In July this year, he had undergone a brain surgery for removal of a clot at the Hinduja Hospital.
"And once again I thank my fans for all the concern and prayers for my health, my treatment is going well and I should be able to resume my life in every way very soon. Thank you," he said.