Khans or other actors do NOT have personality or carefully managed and curated public persona or voice or command over language like Amitabh Bachchan.
Only Rajinikanth comes close to Amitabh model of staying relevant.
 Khans have weak voice, no height or charisma or aura. Aamir especially has NO personality at all and relies on social issues or scripts to stay relevant. Salman relies on mostly looks or style and has bad boy or manchild aura which does not keep one relevant at 80 atleast.
SRK has romantic image and that does not work after a certain age. He has better personality and language skill as well as family man image compared to other Khans and can stay relevant if he makes right choices but he lacks voice, height, aura and ability to reinvent that AB sr has. 
Amitabh is what he is due to his unmatched baritone, command over both Hindi and English, carefully curated public persona, diplomatic ways, ability to take people of all generations along as he sometimes talks like a trad man and sometimes uses new generation woke issues and keeps up with changing trend and technology to stay relevant. Amitabh is also smart enough to cultivate good relations with all parties and is generally respected by all in industry and across political spectrum kind of like Lata ji. He is clever to never get into religion or other issues.
Same cannot be said for other stars. Hema, Rekha also focus on looks and staying relevant. Dharam is another one who is loved at his age.
Khans never had respect that AB Sr had due to his pedigree, impeccable manners, public image, religion, upper caste, elite background and man of the masses type roles he did which made him look like messiah to common repressed Indian masses. Khans never had his political or media management skills either and were too over exposed in their fights or controversies. No Khan has been diplomatic or weathercock like AB sr. They lack his versatility or natural advantage of voice, language, height and commanding screen presence as well.
Khans or any other actor will find it hard to stay relevant like AB Sr, Rajinikanth or reach level of respect that Hema, Rekha, Lata, Dilip, Raj etc had even at 70s or 80s age group.
That is because they are too vocal and came in age of media and 24/7 scrutiny. Also they do not have that caste or religion advantage either nor that personality, image.
Amitabh still does well in KBC which gets good ratings and does different type of roles or roles like Pink which keep him relevant in old age too and strike chord with younger audience. Other actors neither have that personality or connect across all sections of society nor that script sense.
His famous family only keeps him more of an enigma. 
I do not think we have young actors falling at feet of Khans even now the way AB sr was called Bachchan saab even in 1980s and someone like Mithun also used to touch his feet despite being a competitor of sorts in 80s. This kind of stardom and respectable stature is earned only by few and once in several decades. Earlier Dilip, Dev and Raj had this status. 
I will be surprised if any Khan manages to stay as relevant and has fans like AB Sr or Rajinikanth even at 70 plus. And sorry to say, the way some of them lead reckless lifestyle with all alcohol or smoking like chimney, one wonders if even they will live to be 80 or not. 
To answer your question in short, second innings like AB Sr is something others can only dream of. It is not possible for Khans to get it. Aamir may remain relevant as filmmaker or director though or if he does dad roles like Dangal. Salman and SRK will find it difficult to get something substantial after a certain age. Hardest to stay relevant will be Salman as swag cannot sail boat of actor even in old age. He already looks jaded and old in Bigg Boss. 
 
 
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