- Nikita Rai (Nina Myers): Mandira Bedi, who played this role, said she won't be part of the second season, so there isn't much of a chance of her coming back.
- Tejpal Singh Sandhu (Tony Almeida #1): There's a Tony Almeida #2 in the ATU, Vedant Acharya. Given how often the original Tony is believed to have changed sides or operated outside the law, there's a chance that Tej may make a rather villainous return.
- Mahinder Gill (George Mason): This season has little influence of S2 of the original, in which he doesn't last long, so there may not be much for him to do here.
- Divya Singhania (very loosely based on Nicole Palmer): Her re-entry will be the biggest surprise. Maybe mother saves her?
- Saxena (Teddy Hanlin): That grumpy agent who had a problem with Jai and sabotaged his mission- maybe he's a traitor with bigger designs?
With pieces from OR:Season 2 and OR:Season 4 mixed into this season otherwise based on OR:Season 3, and these cast changes, the show may be harder to predict than in its first season.