Posted:
So Yeah Another Medical Term is being touched upon in the show and i cant help myself making this Post.
Also i saw lot of people being confused about the term Oh+. Guys yes this Oh+ do exist but this particular term is like a slang and not prefered. The actual, better, more authentic and Scientific term is hh blood Group or Bombay blood group, A very rare blood type.
Before proceeding further let me clarify one thing Oh+ is actually O+ and H+ which simply cant be put together like Oh+ as a sum up.
We have a whole long list of international systems to Classify blood types. Quoting a few for u all..
1)ABO blood grouping system (Most common and most universally accepted. The one we follow regularly.)
2) Rhesus(Rh system)
3) MNS system
4) Kelly system
5) Bombay blood group/hh blood grouping system
6) Duffy system
7) Diego system
8) Landsteiner W system
Etc. This list is unending
This means our blood groups can be classified in many different types. Foe e.g A person with O+(acc to ABO and Rh system) can also be M+(acc to MNS system) can also be H+(acc to hh system). So they Oh+ is not just sum up but its actually blood grouping acc to 2 different types of classification.. Hope that helps.
What happens in ABO.?
I guess lot of people may be knowing this.
A grouped person - Have A antigen on their RBC's and B antibody on their Serum.
B - have B antigen and A antibody
AB- both A n B antigen, no Antibody
O- No antigen, both Antibodies.
Then whats Positive n Negative?
That is Rhesus system which is Beleived to be an extended version of ABO.
In this, we check for D Antigen.
If D is present - person is + (e.g A+ B+ AB+ O+)
If D is Absent - person is Negative (like A- B- O- AB-)
Untill this its Routine and Common and Universal. We generally dont check for other antigens routinely coz their disorders are very rare.
What happens in Bombay blood Group.?
Its a very Rare blood group type.
Normally what happens is Humans inherit H genes(two allels one from both parents). This H gene codes for H antigen which then(after a whole lot of complex process) form A and B antigen. So basically H antigen is precursor of A and B antigen.
Now in hh blood Type, the H gene(from parents) become mutated(altered, damaged) hence it cannot code for H antigen. No H antigen means No A and B antigen. So phenotypically(what is actually seen from outside) patient is expressed(on blood reports) as O+. There is no other blood group possible for H+ patients. There wont even be A and B antibodies.There will only be H antibodies. Hence the patient can give Blood to anybody(being O) but cant receive blood from anybody(due to H antibody) except a fellow H+ person.
Some few thing about inheritence of Bombay blood group. (If u dont want to know much, u can skip)
1) Most common scenario is Both parents are heterozygous for H gene(Hh)(capital word represents affected gene small word is for normal gene) that means their one set of gene is defective (In heterozygous state Person carries the defect and can also inherit to next gen but doesnt get affected by it)
In this case, child can inherit both of their affected gene like one H from mom and othe H from dad and will become homozygous fod H gene(HH) and will represent/suffer from Disease
2) One parent is Suffering from disease means HH and other is Normal (hh)
In this case child will not suffer and will only be carrier (Hh)
3) One parent is Suffering(HH) while other is carrier(Hh)
Child has both chances, like from one parent he will have H but what he receives from carrier parent will decide his fate. In common scenario he will receive a defective gene to become HH and show the Disease.
This is the case most probably being shown in Nk. Vidyut is having the disease, and he can not alone transfer it to Mishti, Juhi must have an Heterozygous set of Hh. Now that being very deep.
Anyhow It is almost like a paternity test to prove Mishti being Vidyut's Daughter. After this even DNA test ki bhi Jarurt nahi padegi.
I m loving the way Creatives are approaching to this Paternity issue. They can also have shown Mishti to be Juvenile Diabetic, inheriting diabetes from Vidyut. But then Juvenile Diabetes is not always inherited it can even occur as a separate disease to a child whose parents are absolutely normal. But Bombay blood group thing is More concrete.. Loved it.
Also whatever i have written is taken from Standard Reference Text books of MBBS ( Robbins for Pathology, Harrison for Medicine and Kawthalkar for hematology) (They are called Encylopedia for their respective subjects) So kindly spare me the google knowledge. U can even search this books.
I m here if u have any doubt regarding anything. I can explain again.
P.S This Bombay blood discovery was by an Indian(another proud thing for all of us) who is none other than A Late senior Proffessor, a visionary , a co founder of My college KEM Mumbai. So yeah this is special for me.
Sorry.. Gyan kuch jada hi lamba Hogya.
Here i am Singing off.
Open to discussion.!
Also i saw lot of people being confused about the term Oh+. Guys yes this Oh+ do exist but this particular term is like a slang and not prefered. The actual, better, more authentic and Scientific term is hh blood Group or Bombay blood group, A very rare blood type.
Before proceeding further let me clarify one thing Oh+ is actually O+ and H+ which simply cant be put together like Oh+ as a sum up.
We have a whole long list of international systems to Classify blood types. Quoting a few for u all..
1)ABO blood grouping system (Most common and most universally accepted. The one we follow regularly.)
2) Rhesus(Rh system)
3) MNS system
4) Kelly system
5) Bombay blood group/hh blood grouping system
6) Duffy system
7) Diego system
8) Landsteiner W system
Etc. This list is unending
This means our blood groups can be classified in many different types. Foe e.g A person with O+(acc to ABO and Rh system) can also be M+(acc to MNS system) can also be H+(acc to hh system). So they Oh+ is not just sum up but its actually blood grouping acc to 2 different types of classification.. Hope that helps.
What happens in ABO.?
I guess lot of people may be knowing this.
A grouped person - Have A antigen on their RBC's and B antibody on their Serum.
B - have B antigen and A antibody
AB- both A n B antigen, no Antibody
O- No antigen, both Antibodies.
Then whats Positive n Negative?
That is Rhesus system which is Beleived to be an extended version of ABO.
In this, we check for D Antigen.
If D is present - person is + (e.g A+ B+ AB+ O+)
If D is Absent - person is Negative (like A- B- O- AB-)
Untill this its Routine and Common and Universal. We generally dont check for other antigens routinely coz their disorders are very rare.
What happens in Bombay blood Group.?
Its a very Rare blood group type.
Normally what happens is Humans inherit H genes(two allels one from both parents). This H gene codes for H antigen which then(after a whole lot of complex process) form A and B antigen. So basically H antigen is precursor of A and B antigen.
Now in hh blood Type, the H gene(from parents) become mutated(altered, damaged) hence it cannot code for H antigen. No H antigen means No A and B antigen. So phenotypically(what is actually seen from outside) patient is expressed(on blood reports) as O+. There is no other blood group possible for H+ patients. There wont even be A and B antibodies.There will only be H antibodies. Hence the patient can give Blood to anybody(being O) but cant receive blood from anybody(due to H antibody) except a fellow H+ person.
Some few thing about inheritence of Bombay blood group. (If u dont want to know much, u can skip)
1) Most common scenario is Both parents are heterozygous for H gene(Hh)(capital word represents affected gene small word is for normal gene) that means their one set of gene is defective (In heterozygous state Person carries the defect and can also inherit to next gen but doesnt get affected by it)
In this case, child can inherit both of their affected gene like one H from mom and othe H from dad and will become homozygous fod H gene(HH) and will represent/suffer from Disease
2) One parent is Suffering from disease means HH and other is Normal (hh)
In this case child will not suffer and will only be carrier (Hh)
3) One parent is Suffering(HH) while other is carrier(Hh)
Child has both chances, like from one parent he will have H but what he receives from carrier parent will decide his fate. In common scenario he will receive a defective gene to become HH and show the Disease.
This is the case most probably being shown in Nk. Vidyut is having the disease, and he can not alone transfer it to Mishti, Juhi must have an Heterozygous set of Hh. Now that being very deep.
Anyhow It is almost like a paternity test to prove Mishti being Vidyut's Daughter. After this even DNA test ki bhi Jarurt nahi padegi.
I m loving the way Creatives are approaching to this Paternity issue. They can also have shown Mishti to be Juvenile Diabetic, inheriting diabetes from Vidyut. But then Juvenile Diabetes is not always inherited it can even occur as a separate disease to a child whose parents are absolutely normal. But Bombay blood group thing is More concrete.. Loved it.
Also whatever i have written is taken from Standard Reference Text books of MBBS ( Robbins for Pathology, Harrison for Medicine and Kawthalkar for hematology) (They are called Encylopedia for their respective subjects) So kindly spare me the google knowledge. U can even search this books.
I m here if u have any doubt regarding anything. I can explain again.
P.S This Bombay blood discovery was by an Indian(another proud thing for all of us) who is none other than A Late senior Proffessor, a visionary , a co founder of My college KEM Mumbai. So yeah this is special for me.
Sorry.. Gyan kuch jada hi lamba Hogya.
Here i am Singing off.
Open to discussion.!
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