Ladies Special revolves around the lives of 3 passengers who meet in a Mumbai Ladies Special train & become friends, sharing their problems with each other while commuting to work. The three protagonists - Prarthana, Meghna and Bindu face all adversities in life together & continue marching forward with the hope of a brighter future.

Ladies Special which went off air on 14th Decemeber 2009 came up with a new season with an entirely new cast and plot on 27th November 2018. It is produced by optimystix Entertainment and it airs on Sony TV at 9.30 pm from Monday to Friday.