Shraddha Arya as Dr. Preeta Arora Luthra: Sarla and Raghuveer's second daughter; Pragya, Bulbul and Srishti's sister; Karan's wife; Pihu's adoptive mother; Rishabh's ex-wife; Kavya, Rajveer and Shaurya's mother (2017–present)
Dheeraj Dhoopar as Karan Luthra: Rakhi and Mahesh's younger son; Rishabh and Ruchika's brother; Sameer and Kritika's cousin; Preeta's husband; Pihu's adoptive father; Kavya, Rajveer and Shaurya's father; Nidhi's illegitimate husband (2017–2022)
Shakti Arora replaced Dhoopar as Karan Luthra (2022–2023)
Shakti Anand replaced Arora as Karan Luthra (2023–present)
Manit Joura as Rishabh Luthra: Rakhi and Mahesh's elder son; Karan and Ruchika's brother; Sameer and Kritika's cousin; Sherlyn and Preeta's ex-husband; Kavya, Rajveer and Shaurya's uncle (2017–2021; 2022–present)
Paras Kalnawat as Rajveer Luthra: Preeta and Karan's elder son; Pihu's adoptive brother; Kavya's younger and Shaurya's twin brother; Palki's love-interest (2023–present)
Baseer Ali as Shaurya Luthra: Preeta and Karan's younger son; Pihu's adoptive brother; Kavya's younger and Rajveer's twin brother; a rap artist (2023–present)
Sana Sayyad as Dr. Palki Khurana: Shailendra and Daljeet's eldest daughter; Shanaya and Mahi's elder sister; Rajveer's love-interest; Ketan's ex-fiancée; Dr. Avinash's assistant; Bani's doctor (2023–present)
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