Sohail Khan was born into a family with strong ties to the Bollywood film industry: His father is Salim Khan, a successful scriptwriter and his mother is Salma Khan, while his step-mother is dancer and Bollywood actress Helen. His older brothers are actors Arbaaz Khan and Salman Khan. His sister, Alvira Khan, is married to Bollywood actor Atul Agnihotri, while his younger sister Arpita Khan "discovered" Sneha Ullal for his movie Lucky: No Time for Love, which he produced with his production company "Sohail Khan Production". He is married to Seema Sachdev and has one son Nirvaan Khan who was born on December 20, 2000.
Sohail Khan started his career as a film producer and director making his directorial debut with the 1997 action thriller Auzaar which starred his brother Salman and Sanjay Kapoor. He then directed both of his brothers Salman and Arbaaz in the hit film Pyaar Kiya To Darna Kya (1998) and the less successful Hello Brother (1999).
In 2002 he wrote, produced, directed and made his acting debut in Maine Dil Tujhko Diya which did not do well at the box office and failed to launch his career as an actor. He then appeared in a few more films, none of which did well at the box office. He had his first hit with the film Maine Pyaar Kyun Kiya? (2005) in which he co-starred with brother Salman. He also wrote the story, produced and starred in the multi-starrer Fight Club - Members Only which also did not do well at the box office. In 2006 he starred in the boxing drama Aryan for which his performance was appreciated but the film failed to do well as it was a delayed release.
His only 2007 release as an actor was the multi-starrer Salaam-e-Ishq: A Tribute To Love. He then produced Partner which starred his brother Salman and Govinda in the lead roles and was a huge box office success.
He has also announced to star for the first time with both his brothers Salman and Arbaaz in Amar Akbar Anthony a remake of the 1977 Manmohan Desai film of the same name