I too like Vishal and Neha as Vishnu and Lakshmi. They both look great in their roles and they look well as a couple also. I'm really eager to see them as Krishna and Rukmini if the show plans to go that far (which I hope it will!).
I like that Vasudev and Devaki are getting a lot of attention in this show, I just wish it was done in a better way at times. Both of them individually are not too bad, but as a couple they're kind of awkward.
I liked the sequence of Balaram's birth. Weird as it was for Rohini to be in the prison with them, the trio worked well together and Rohini's subsequent escape, Sesh Naag protecting her, and then her pregnancy/delivery were shown well.
I like Nand and Yashoda together. Some of their scenes are really cute, though Yashoda's depression over not conceiving was overdone for a while.
Krishna's birth was, like Lola said, underwhelming, but the trip to Gokul was awesome and the actor who plays Vasudev was great with baby Krishna. The last glimpse between them was so heartfelt.