"Brothers", which features Akshay Kumar and Sidharth Malhotra as estranged siblings pitted against each other, has amassed Rs.52.08 crore in its opening weekend in India.
The action-packed family drama collected Rs.15.45 crore nett at the box office on Sunday, a statement said.
"Brothers" shows Akshay doing mixed martial arts along with Sidharth.
Directed by Karan Malhotra, the film is presented by Fox Star Studios.
The Dharma Productions film also stars Jacqueline Fernandez and Jackie Shroff.
Celebrities like Hrithik Roshan, Sonakshi Sinha and Arshad Warsi used words like "outstanding", "very dramatic and the best sports action" film and "an emotional family saga interlaced with the exciting world of MMA (mixed martial arts)" to describe the film.